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Nantong Fangbing Chemical Co., Ltd.
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What are the precautions for phenylhydrazine

Phenylhydrazine is used to prepare dyes, drugs, imaging agents, etc.; it is an important carbonyl reagent, usually used to identify aldehydes, ketones and sugars. Phenylhydrazine can be prepared by reducing diazobenzene chloride or aniline diazotization, and then treating with sodium sulfite and sodium hydroxide.

Health hazards: This product can cause hemolytic anemia, methemoglobinemia, hyperbilirubinemia, and damage the central nervous system, liver, kidneys and heart. Acute poisoning: mild poisoning includes headache, dizziness, weakness, loss of appetite, abdominal pain, diarrhea, etc. More serious symptoms of poisoning include difficulty breathing, convulsions, tremors, and even ataxia and confusion. In severe cases, purple osis, jaundice, leukopenia, hemolytic anemia, hyperbilirubinemia, liver and kidney damage may occur. Chronic poisoning: Long-term exposure can cause heart, liver and kidney damage. It may cause skin damage, severe blisters, edema, etc.

Environmental hazards: harmful to the environment.

Explosion hazard: The product is flammable and toxic.

Hazardous characteristics: flammable. It is combustible under open flame and high heat.

When heated, it decomposes and releases toxic nitrogen oxide fumes. A chemical reaction can occur in contact with strong oxidants. The results of the acute toxicity test of phenylhydrazine showed that phenylhydrazine was effective in the LD of mice (50 mice)=166.9mg/kg; the hemoglobin content gradually decreased, the number of red blood cells decreased sharply, and the index change showed a linear change with time within 72h. The number of white blood cells increased significantly within 48 hours and then decreased. At the same time, the above three indicators have extremely significant differences between the 148.6 mg/kg, 166.0 mg/kg and 185.4 mg/kg dose groups and the control group. The activity of serum alanine aminotransferase and aspartate aminotransferase increased significantly. It can be seen from the above that phenylhydrazine is a moderately toxic substance, which can destroy VAT cells and seriously damage the liver.

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