Phenylhydrazine for medicine

Phenylhydrazine for medicine is a synthetic hydrazine derivative, usually used as an intermediate for organics, dyes, drugs and pesticides. Organic intermediates, such as pyrazoline, triazole and indole; dye intermediates, such as 1-phenyl-3-methyl-5-pyrazolone; pharmaceutical intermediates, such as antipyretics, analgesics and anti-inflammatory drugs ; Photographic drugs (photosensitive pigments) and phenylhydrazine are also the raw materials for the production of pesticide insecticide "Dasha phosphorus"; phenylhydrazine is also a heavy pesticide. Carbonyl identification reagents are used to identify aldehydes, ketones and sugars.

Phenylhydrazine is prepared by reacting aniline and sodium nitrite in hydrochloric acid to form diazonium salt, and then reducing it with sodium sulfite/sodium hydroxide. Phenylhydrazine hydrochloride is produced by acid precipitation, while phenylhydrazine is obtained by neutralization. Phenylhydrazine is used in the synthesis of Fischer indole with aldehydes and ketones to obtain the indole ring system, so it is a synthetic intermediate for many drugs, dyes and pesticides. It can react with benzaldehyde to form phenylhydrazone. The latter is also a common synthetic intermediate in industry. 2,4-Dinitrophenylhydrazine, a derivative of phenylhydrazine, used to identify aldehydes and ketones. Phenylhydrazine is toxic and may cause contact dermatitis, hemolytic anemia, liver and kidney damage.